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NT-Pro B type Natriuretic Peptide (BNP)

Performing Lab(s)

Memorial-Belleville & Memorial-Shiloh

Specimen Requirement (s)

Specimen Type: plasma (preferred) or serum

Container/Tube:   Mint green (LiHep) tube (preferred), Lavender (EDTA) tube, white (K3EDTA) PPT, SST (gold or marble)  or plain red top

Specimen Volume:  at least 3/4 full tube

Specimen Minimum Volume:  2 mL

 

Collection Instructions:

  • Invert after collection of plasma tubes
  • Must be brought to the lab within 1 hour of collection.

 

Lab instructions: NA

Day(s)/Shift(s) Test Set Up and Turnaround Time

Sunday through Saturday

Hours: 24 hours

 

Turnaround Time:

STAT: 60 minutes

Routine: less than 8 hours from receipt.

Transport and Stability

Transport temperature: Ambient to lab

Reference Values

NT-Pro BNP

Age

Reference Values

0 – 74 years

< 300 pg/mL

> 75 years

< 450 pg/mL

 

CPT/LOINC Codes

83880

Interpretive Data

 

Interpretive Comments:

A. Dyspnea in Acute Care Setting

All Ages: < 300 pg/ml, acute heart failure unlikely.

< 50 yrs: 300 - < 450 pg/ml, further investigation warranted.

               > 450 pg/ml, acute heart failure likely.

50 - 74 yrs: 300 - < 900 pg/ml, further investigation warranted.

                    > 900 pg/ml, acute heart failure likely .

≥ 75 yrs: 450 - < 1800 pg/ml, further investigation warranted.

                        > 1800 pg/ml, acute heart failure likely.

B. Non-acute Setting

< 75 yrs  < 125 pg/ml, rules out heart failure.

                ≥ 125 pg/ml, further investigation warranted.

≥ 75 yrs  < 450 pg/ml, rules out heart failure.

               ≥ 450 pg/ml, further investigation warranted.

 

Knowledge of each individual patient's NT-proBNP range may be more useful than using similar cut-points for every patient.

Please note that marked elevations in NT-proBNP levels may be observed in state other than Left Ventricular Congestive Failure, including: acute coronary syndromes, right heart strain/failure (including pulmonary embolism and cor pulmonale), critical illness, renal failure, as well as advanced age.

 

References:

1. Januzzi JL et.al. Eur Heart J. 2006:27:330-337.

2. Troughton RW, Richards AM. J. AM Coll Cardiol: Cardiovasc Imag. 2009;2: 216-225.

Interpretive Data Last Revised Date: 8/21/2018.