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Digoxin

Additional Codes

Epic# -

LAB23

 

Cerner name(s):

  • Digoxin Level
  • Digoxin

 

Performing Lab(s)

Memorial-Belleville & Memorial-Shiloh

Specimen Requirement (s)

Specimen Type: plasma (preferred) or serum

Container/Tube:   Mint green LiHep tube (preferred),  lavender (EDTA) top, red top or SST (gold or marble)

Specimen Volume:     2 mL

Specimen Minimum Volume:  1 mL

 

Collection Instructions:

  • When digoxin is administered by IV the collection time is at least 4 hours after the dose.
  • When digoxin is administered by mouth the collection time is at least 6 hours after the dose. The optimum collection time is 12 – 24 hours after the dose.

Day(s)/Shift(s) Test Set Up and Turnaround Time

Sunday through Saturday

Hours: 24 hours

 

Turnaround Time:

STAT: 60 minutes

Routine: less than 1 hours from receipt.

Transport and Stability

Transport temperature: Ambient to lab

 

Analyte Stability: 

Ambient: 72 hours

Refrigerated: 72 hours

Frozen: NA

Reference Values

Therapeutic: 0.5 - 1.2 ng/mL

 

Critical High: > 2.3 ng/mL

Interpretive data

The therapeutic range for digoxin varies by indication:

Heart failure: 0.5 to 0.8 ng/mL

Atrial fibrillation: less than 1.2 ng/mL

Toxicity: >2.4.

Normal or low digoxin does not rule out toxicity.

Current interpretive data was last revised on 09/01/2024.

Additional Information

  1. Endogenous substances such as DLIF (Digoxin-like immunoreactive factors) may interfere with this assay by yielding slightly elevated results. DLIF are observed primarily in samples from neonates, pregnant women, and acute care patients with renal or hepatic failure.
  2. The manufacturer of Digoxin Immune Fab (Antibody fragment therapy) has stated that no immunoassay technique is suitable for quantitating Digoxin in serum from patients undergoing this treatment.

CPT/LOINC Codes

80162